Panes Layout Load/Save new Pane

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GetDockingPaneManager()->CreatePane(IDC_PANE1, CRect(0,0,200,300), dockBottomOf, NULL);
GetDockingPaneManager()->CreatePane(IDC_PANE2, CRect(0,0,200,300), dockBottomOf, NULL);

//  here GetDockingPaneManager()->CreatePane(IDC_PANE3, CRect(0,0,200,300), dockBottomOf, NULL);

 m_pDefaultLayout = GetDockingPaneManager()->CreateLayout();
GetDockingPaneManager()->GetLayout(m_pDefaultLayout);

m_pPaneLayout = GetDockingPaneManager()->CreateLayout();
if (m_pPaneLayout->Load(_T("PaneLayout")))
        {
        GetDockingPaneManager()->SetLayout(m_pPaneLayout);
        }
  else
        GetDockingPaneManager()->GetLayout(m_pPaneLayout);

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Run one.
remove comments.
After SetLayout, the IDC_PANE3 are destroyd.

    Jimmy

..or even better, clean up the old PanelLayout structure in registry, at program launch. You need a version identifier somewhere which control to delete or not. I prefer this vs. creating "PanelLayout_v2" to avoid cluttering the registry too much ...